Journal article
Endogenous progesterone levels and frontotemporal dementia: Modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model
TNT Dang, C Dobson-Stone, EN Glaros, WS Kim, M Hallupp, L Bartley, O Piguet, JR Hodges, GM Halliday, KL Double, PR Schofield, PJ Crouch, JBJ Kwok
Dmm Disease Models and Mechanisms | COMPANY OF BIOLOGISTS LTD | Published : 2013
DOI: 10.1242/dmm.011460
Abstract
Frontotemporal dementia (FTD) is associated with motor neurone disease (FTD-MND), corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). Together, this group of disorders constitutes a major cause of young-onset dementia. One of the three clinical variants of FTD is progressive nonfluent aphasia (PNFA), which is focused on in this study. The steroid hormone progesterone (PROG) is known to have an important role as a neurosteroid with potent neuroprotective and promyelination properties. In a case-control study of serum samples (39 FTD, 91 controls), low serum PROG was associated with FTD overall. In subgroup analysis, low PROG levels were significantly associated wit..
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Awarded by National Science Foundation
Funding Acknowledgements
This study is funded by NHMRC project grants APP1005769 (C.D.-S., J.B.J.K.), APP1029538 (G.M.H., J.R.H.) and APP1005651 (P.J.C.), and a Brain Foundation Research grant (P.J.C.). J.R.H. has an ARC Federation Fellowship. G.M.H. has aN NHMRC Senior Principal Research Fellowship 630434. K.L.D. has an NHMRC Senior Research Fellowship 401101. O.P. is supported by an NHMRC Career Development Fellowship (APP1022684).